Developmental Hematopoiesis - Preface

Developmental hematopoiesis in normal human fetal blood.

Using an easy and safe procedure for fetal blood sampling in utero, we studied 3,415 fetuses for prenatal diagnosis. Retrospectively, 2,860 normal blood samples, performed from the 18th week of gestation to the end of pregnancy, were selected. Differentials were evaluated in 732 cases. Burst-forming unit erythroid (BFU-E) and erythropoietin (Epo) were measured in 27 and 163 cases, respectively....

PREFACE

Preface

PREFACE

HEMATOPOIESIS AND STEM CELLS Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis

Dissecting the molecular mechanisms used by developmental regulators is essential to understand tissue specification/ differentiation. SCL/TAL-1 is a basic helixloop-helix transcription factor absolutely critical for hematopoietic stem/progenitor cell specification and lineage maturation. Using in vitro and forced expression experimental systems, we previously suggested that SCL might have DNA-...